Semi-Solid Dosage Forms - Contract Pharma.

Semisolid Dosage Forms - products intended to be applied on skin (epicutaneous route) and mucous membranes - cling to the skin or mucous membrane for a prolonged period of time to exert their therapeutic benefits.

Gels and jellies are semisolid system in which a liquid phase is constrained within a 3-D polymeric matrix having a high degree of physical or chemical cross-linking. Gels are aqueous colloidal suspensions of the hydrated forms of insoluble medicament. Jellies are transparent or translucent non-greasy semisolid and contains more water than gels.

Types of dosage forms: Definition: Dosage forms are the means by which drug molecules are delivered to sites of action within the body. The need for dosage forms: 1- Accurate dose. 2- Protection e.g. coated tablets, sealed ampules. 3- Protection from gastric juice. 4- Masking taste and odour. 5- Placement of drugs within body tissues.

Abstract The objective of present study was to document the requirements for manufacturing of semisolid dosage forms. These guidelines also brief about some issues associated with tools.

Drugs are given in different forms. There are many forms of drugs to suit the needs of the individual patients. A same drug is made in different forms for ease of administration, pharmacology and patient related factors. For example, pain killers like diclofenac is available as tablet, injection and even ointment. Tablets can be consumed voluntarily by the patient for its effect on whole of.

Based on United State Pharmacopeia, pastes are defined as semisolid dosage forms that contain one or more drug substances intended for topical application. (Pharmaceutical Dosage Form, 2009) Pastes are intended for application to the skin, oral cavity, or mucous membranes.

NCI Thesaurus OID: 2.16.840.1.113883.3.26.1.1. NCI concept code for pharmaceutical dosage form: C42636.

Introduction and classification of dosage forms. The form in which drug substances are presented in the market are called the dosage forms. A dosage form may be solid, semisolid, liquid or gas and contains a definite quantity of drug(s) along with or without excipients.

INTRODUCTION: Topical semisolid dosage forms are normally presented in the form of creams, gels, ointments, or pastes. They contain one or more active ingredients dissolved or uniformly dispersed in a suitable base and any suitable excipients such as emulsifiers, viscosity increasing agents, antimicrobial agents, antioxidants, or stabilizing agents.

These include drug molecules that are in a suitable solid base (e.g., powders and aerosols), semi-solid base (e.g., ointments, creams, foams, gels, poultice and pastes), or in liquid form (e.g., solutions, suspension of solids in aqueous solutions or emulsions) which possesses either hydrophobic or hydrophilic properties.

Pharmaceutical semisolid dosage preparations include ointments, pastes, cream, gels These preparations are usually used topically (ie. Applied on the body surfaces - skin, or mucous membranes) Ointments Ointments are homogeneous, semi-solid prepar.

Tablets are solid dosage form manufactured either by dry granulation, wet granulation or direct compression containing medicaments with or without excipients, intended to produce desired pharmacological response. Various types of tablets (1-15) are being manufactured according the route of administration and type of dosage form.